Zotepine Versus Risperidone in Aggressive Schizophrenic Patients of Acute Ward

A Multi-centre Comparative Study to Evaluate the Anti-aggression Effect and Safety of Zotepine Versus Risperidone in Aggressive Schizophrenic Patients of Acute Ward

The purpose of this study is to compare the efficacy and tolerability of zotepine versus Risperidone in aggressive schizophrenic patients.

Inclusion Criteria:

• Aged 18 to 65 years, male or female
• In-patients suffering from schizophrenia according to DSM-IV diagnostic criteria with PANSS total score of greater than or equal to 60.
• Patients with PANSS-EC total score of greater than or equal to 14 and with at least one PANSS-EC symptom score greater than or equal to 4

Exclusion Criteria:

• Patients with history of seizure or with alcohol or substance abuse in the last 6 months
• Diabetes, Parkinson's disease or phaeochromocytoma
• Patients with hypertension and current use of antihypertensive agents
• Women who are pregnant, lactating or intend to become pregnant during the study period
• Poor response to two different antipsychotics in full dose and full course or use of clozapine previously
• Renal, hepatic, haematologic disease or other conditions may not suitable for the study based on investigator's evaluation