Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to investigate whether an angiotensin II receptor blocker (olmesartan), in addition to conventional treatment, will reduce the mortality and morbidity in hypertensive patients with stable chronic heart failure.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Olmesartan medoxomil | Active Comparator | olmesartan medoxomil |
|
| Standard therapy | No Intervention | Standard therapy |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| olmesartan medoxomil | Drug | 5 to 40mg P.O. daily until the end of the study |
|
| Measure | Description | Time Frame |
|---|---|---|
| A composite of the following outcomes 1) all-cause death 2) nonfatal acute myocardial infarction 3) nonfatal stroke 4) hospital admission due to congestive heart failure | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| Measure | Description | Time Frame |
|---|---|---|
| cardiovascular death | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| death due to heart failure | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. |
| Measure | Description | Time Frame |
|---|---|---|
| serum markers for metabolic syndrome | Blood sampling was performed at the time of and 3 years after randomization. Changes in serum levels of markers for metabolic syndrome (high sensitive C-reactive protein, adiponectin, microRNAs) were examined . | three years |
Inclusion Criteria:
Patients who meet all of the following criteria.
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Hiroaki Shimokawa, MD, PhD | Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine | Sendai | 980-8574 | Japan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25637937 | Derived | Sakata Y, Shiba N, Takahashi J, Miyata S, Nochioka K, Miura M, Takada T, Saga C, Shinozaki T, Sugi M, Nakagawa M, Sekiguchi N, Komaru T, Kato A, Fukuchi M, Nozaki E, Hiramoto T, Inoue K, Goto T, Ohe M, Tamaki K, Ibayashi S, Ishide N, Maruyama Y, Tsuji I, Shimokawa H; SUPPORT Trial Investigators; SUPPORT Trial Investigators. Clinical impacts of additive use of olmesartan in hypertensive patients with chronic heart failure: the supplemental benefit of an angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial. Eur Heart J. 2015 Apr 14;36(15):915-23. doi: 10.1093/eurheartj/ehu504. Epub 2015 Jan 30. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000068557 | Olmesartan Medoxomil |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| by the end of the study |
| sudden death | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| acute myocardial infarction | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| stroke | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| hospital admission from any cardiovascular reasons | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| fatal arrhythmia or appropriate ICD discharge | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| new-onset diabetes | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| development of renal failure | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| new-onset atrial fibrillation | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| a need to modify treatment procedures for heart failure | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| left ventricular ejection fraction | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| B-type natriuretic peptide | All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013. | by the end of the study |
| D013777 |
| Tetrazoles |