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The aim of the protocol is to study the resting brain activation profile of 3 groups of people, using a new fMRI procedure, called fMRI-SAM. fMRI-SAM will be applied to 25 Alzheimer's disease (AD) patients, 25 patients suffering from amnestic - mild cognitive impairment (MCI) - a clinical picture which may be a prodromal form of AD - and 60 healthy controls. The first analysis of the data will search differences of brain activation profiles between the 3 groups. In the second step, the investigators will study the predictive value of fMRI-SAM to detect MCI patients who will later convert to AD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ALZHEIMER DISEASE | Other |
| |
| MOLD COGNITIVE IMPAIRMENT | Other |
| |
| CONTROLS | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fMRI to detect MCI patients who will convert to Alzheimer's disease | Procedure | There is a fMRI to be realized in the 3 arms. No drug is administered |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparing fMRI data between 3 groups of subjects: MCI, Alzheimer's disease and normal subjects | 1, 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Follow-up of MCI patients at 6, 12 and 18 months to detect a conversion to Alzheimer's disease | Prediction of Alzheimer's disease on fMRI data |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Francois Sellal, MD | Hôpitaux Universitaires de Strasbourg | Principal Investigator |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |