Effects Of The Drug Ketoconazole On How The Body Handles The Drug SB773812

Open Label Study in Healthy Volunteers to Investigate the Effect of Ketoconazole 400mg on Pharmacokinetics of SB-773812 20mg

The purposes of this study are to determine if there is a difference in how SB-773812 is distributed through the bloodstream before and after multiple doses of ketoconazole have been given and to determine if there is a difference in how safe and well tolerated SB-773812 is when given on its own and given with ketoconazole.

Inclusion criteria:

• Healthy
• Body Weight >/=50kg and BMI 18.5-29.9 kg/m2 inclusive
• Normal 12-lead ECG, physical examination and lab screen

Exclusion criteria:

• A history of psychiatric illness,
• A history or presence gastro-intestinal,
• A hepatic or renal disease or orthostatic hypotension.