Urodynamic Effects of UK-369,003 in Men With Lower Urinary Tract Symptoms

A Multi Center Randomized Cross Over Double Blind Third Party Open Placebo Controlled Pilot Study to Assess the Urodynamic Effects of Modified Release UK-369,003 in Men With Lower Urinary Tract Symptoms.

This is a pilot study to generate hypotheses about the urodynamic effects of UK-369,003 in men with lower urinary tract symptoms.

Inclusion Criteria:

• Male subjects, aged 40 years and above, with documented LUTS with an International Prostate Symptom Score (IPSS) ≥13.
• Clinical diagnosis of BPH
• Qmax 5 to 15 ml/sec with a voided volume of ≥150 ml
• Urodynamically defined bladder outlet obstruction

Exclusion Criteria:

• prostate cancer
• Post-void residual urine volume >200 ml
• Documented UTI
• History of relevant urological surgery