Purpose of the study is to evaluate use of electronic diaries and voice acoustics for use in future depression clinical trial. Focus is on increased precision of measurement.

Inclusion Criteria:

• Primary diagnosis of Major Depressive Disorder with symptoms of depression present at least 1 month
• Psychotropic medications currently not being taken

Exclusion Criteria:

• Failure to respond in past 5 years to antidepressant therapy of adequate duration and dosing
• Diagnoses of following conditions or disorders within past 6 months: generalized anxiety, obsessive compulsive, panic, post stress, anorexia, bulimia, alcohol or substance abuse or social anxiety disorder
• Diagnoses current or past of the following conditions or disorders: schizophrenia, psychotic disorder, delieium, dememtia, amnestic cognitive disorder, bipolar