Carboplatin and ABI-007 in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery | NCT00404235 | Trialant

Carboplatin and ABI-007 in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery | NCT00404235 | Trialant

Official Title: A Phase II Trial of Carboplatin (CBDCA) and ABI-007(ABX) in Patients With Unresectable Stage IV Melanoma
Brief Summary: RATIONALE: Drugs used in chemotherapy, such as carboplatin and ABI-007, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.

PURPOSE: This phase II trial is studying the side effects and how well giving carboplatin together with ABI-007 works in treating patients with stage IV melanoma that cannot be removed by surgery.
Detailed Description: OBJECTIVES:

Primary

Assess the safety and antitumor activity of carboplatin and paclitaxel albumin-stabilized nanoparticle formulation (ABI-007) in patients with unresectable stage IV melanoma who have not received prior chemotherapy for their metastatic disease. (Cohort 1)

Assess the safety and antitumor activity of this regimen in patients with unresectable stage IV melanoma who have received prior chemotherapy for their metastatic disease. (Cohort 2)

Secondary

Describe the impact of this regimen on parameters of immune function and angiogenesis in these patients.

OUTLINE: This is a multicenter study. Patients are stratified according to prior chemotherapy for metastatic disease (yes vs no).

Patients receive paclitaxel albumin-stabilized nanoparticle formulation (ABI-007) IV over 30 minutes followed by carboplatin IV over 30 minutes on days 1, 8, and 15. Treatment repeats every 28 days for at least 8 courses in the absence of disease progression or unacceptable toxicity.

Blood and tumor tissue samples are collected periodically to evaluate secreted protein acidic and rich in cysteine (SPARC) content of tumor tissue by immunohistochemistry and to explore the impact of therapy on immune homeostasis. Samples are also analyzed by immunoenzyme techniques for angiogenesis markers.

After completion of study treatment, patients are followed periodically for up to 2 years.

PROJECTED ACCRUAL: A total of 74 patients will be accrued for this study.

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: DISEASE CHARACTERISTICS:

Histologically or cytologically confirmed unresectable stage IV melanoma

Measurable disease

Must have formalin-fixed, paraffin-embedded tumor tissue available for secreted protein acidic and rich in cysteine (SPARC) analysis pre-treatment (Mayo Clinic patients must be willing to submit a repeat biopsy at time of tumor progression)

Brain metastases allowed provided they were previously treated with no progression for ≥ 3 months

Patients with known brain metastases may receive concurrent steroid treatment

PATIENT CHARACTERISTICS:

ECOG performance status 0-2

Life expectancy ≥ 3 months

Absolute neutrophil count ≥ 1,500/mm^3

Platelet count ≥ 100,000/mm^3

Hemoglobin ≥ 9 g/dL (may be transfused to meet this requirement)

Creatinine ≤ 1.5 times upper limit of normal (ULN)

Total bilirubin ≤ 1.5 times ULN (elevated bilirubin allowed in patients with documented Gilbert's syndrome)

AST ≤ 2.5 times ULN

Alkaline phosphatase ≤ 2.5 times ULN

Not pregnant or nursing

Negative pregnancy test

Fertile patients must use effective contraception during and for 1 month after completion of study therapy

No uncontrolled intercurrent illness including, but not limited to, the following:

Active infection

Congestive heart failure (New York Heart Association class III-IV heart disease)

No peripheral neuropathy ≥ grade 2

No other malignancy within the past 5 years except basal cell or squamous cell carcinoma of the skin previously treated with local resection only or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY:

See Disease Characteristics

Recovered from prior therapy

At least 4 weeks since prior radiotherapy

At least 4 weeks since prior interferon or interleukin-2

At least 4 weeks since prior chemotherapy (cohort 1 )

No prior chemotherapy in the metastatic setting (cohort 2)

No prior treatment for melanoma with any of the following agents:

Platinum chemotherapy (e.g., carboplatin or cisplatin)

Taxanes (e.g., paclitaxel or docetaxel)

Paclitaxel albumin-stabilized nanoparticle formulation (ABI-007)

No other concurrent chemotherapy

No other concurrent investigational agents

No concurrent radiotherapy, including palliative radiotherapy