The purpose of the study is to determine the appropriate dose of fluticasone propionate/formoterol fumarate that is closest to Advair Diskus (fluticasone propionate/salmeterol xinafoate using pulmonary function, safety, and levels of study drug in blood plasma in patients with chronic obstructive pulmonary disease.

Inclusion Criteria:

• Diagnosis of COPD
• Female of child-bearing potential to use adequate birth control
• Smoker or ex-smoker with history of at least 10 years of smoking at least one pack of cigarettes per day
• Meet lung function requirements

Exclusion Criteria:

• Diagnosis of asthma
• Other significant disease than COPD
• Pregnant or lactating female
• Female planning to become pregnant