Efficacy and Safety Study of Esomeprazole vs Omeprazole to Treat Acute Non-Variceal Upper Gastrointestinal Bleeding

A Randomised, Double-Blind, Double-Dummy, Active-Controlled, Multicenter Study to Assess the Efficacy and Safety of Esomeprazole or Omeprazole for 5 Days in Subjects With Acute Non-Variceal Upper Gastrointestinal Bleeding

The purpose of this study is to assess the efficacy and safety of Esomeprazole and Omeprazole intravenous every 12 hours for 5 days in subjects with acute non-variceal upper gastrointestinal bleeding

Inclusion Criteria:

• Male or female aged 18-65 years.
• GI bleeding or with such signs within 48 hours as judged by the investigator as to have non-variceal upper GI bleeding.
• One endoscopically confirmed bleeding peptic ulcer or erosive gastritis

Exclusion Criteria:

• GI bleeding caused by Esophageal varices
• Mallory Weiss syndrome
• Zollinger-Ellison syndrome
• Suspicion of gastric malignancy at baseline endoscopy
• Post-Billroth-resection
• Unknown source of GI bleeding · 2.Unstable vital signs