Upper GI Handling of Branded vs. Generic Alendronate

A Randomized, Single-Blind Study to Evaluate Upper Gastrointestinal Handling of Branded Versus Generic Alendronate Tablets

To compare upper GI handling of fosamax and generic, because the main AE profile of alendronate is before systemic absorption in the esophagus; differences could be relevant to the side effect profile.

Inclusion Criteria:

• Post-menopausal females aged greater 55 years
• Prescribed alendronate 70 mg tablets for a therapeutic indication throughout the previous 3 months and expected to continue on this treatment for the duration of the study
• Willing to abstain from alcohol for 24 hours before each dose and until the end of each study day
• Willing to abstain from smoking for 24 hours before each dose and until the end of each study day

Exclusion Criteria:

• History of drug hypersensitivity
• Suffers from dysphagia, achalasia, or other conditions or medications affecting upper gastrointestinal motility