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The purpose of this study is to assess the safety and effects of VX-702 in subjects with moderate to severe rheumatoid arthritis and who are taking the drug methotrexate.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VX-702 | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the effects of VX-702 administered with concomitant methotrexate (MTX), and MTX alone |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate the safety and tolerability of VX-702 administered with concomitant MTX, and MTX alone |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert Kauffman, MD, PhD | Vertex Pharmaceuticals Incorporated | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Call For Information | Dimitrovgrad | Bulgaria | ||||
| Call For Information |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19404957 | Derived | Damjanov N, Kauffman RS, Spencer-Green GT. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009 May;60(5):1232-41. doi: 10.1002/art.24485. |
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| Pleven |
| Bulgaria |
| Call For Information | Sofia | Bulgaria |
| Call For Information | Veliko Tarnovo | Bulgaria |
| Call For Information | Osijek | Croatia |
| Call For Information | Zagreb | Croatia |
| Call For Information | Bytom | Poland |
| Call For Information | Krakow | Poland |
| Call for Information | Torun | Poland |
| Call For Information | Żyrardów | Poland |
| Call For Information | Novosibirsk | Russia |
| Call For Information | Saint Petersburg | Russia |
| Call For Information | Saratov | Russia |
| Call For Information | Belgrade | Serbia and Montenegro |
| Call For Information | Niska Banja | Serbia and Montenegro |
| Call For Information | Zemun | Serbia and Montenegro |
| Call For Information | Ljubljana | Slovenia |
| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| C517771 | VX 702 |
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