Recently published studies demonstrated very high event free survival for patients with a normal interim PET/CT and a high hazard ratio for progression of an interim positive (pathological)study. These findings strongly support the integration of interim PET as a decision point for adjustment of chemotherapy.This study use the minimal therapy considered safe according to the predefined risk factors for patients with interim negative PET. Those with pathologic interim study considered as higher risk patients will have dose escalation of therapy.remission rate ,event free survival and overall survival will be evaluated.

study aim is to tailor the therapy in order to administer the lowest cumulative dose of therapy yet considered safe in order to reduce both early and late therapy related complications.

patients will be divided according to risk factors to sub groups of early favorable, early unfavorable, advanced disease with score less then 3 points or higher then 3 points.

Early Interim PET will be carried out Further therapy will be based on the study results.

Inclusion Criteria:

• Hodgkin lymphoma patients
• age 18-60 for those with early disease and advanced disease with score less then 3
• age 18-60 years for patients with advanced disease score 3 or higher classical Hodgkin lymphoma
• WBC more then 3500
• platelets more then 100000
• creatinin less then 2.0 mg
• bilirubin less then 2.0 mg
• absolute neutrophil count more then 1000 unless bone marrow involvement If marrow involve, patient with lower count but ANC of 1000 may be included.

Exclusion Criteria:

• Positive serology for HIV
• bilirubin more then 2 mg/dl
• creatinin more then 2 mg/dl
• lactating woman or pregnant
• patient older then 60 years with high risk disease of score 3 or more