Gabapentin Treatment of Alcohol Dependence

Gabapentin Treatment of Alcohol Dependence

Gabapentin treatment for alcohol dependence

This is a 12-week, double blind, placebo controlled, dose ranging study to evaluate the efficacy of gabapentin in treating outpatients with alcohol dependence. Subjects receive 900mg or 1800mg gabapentin or placebo daily for 12 weeks accompanied by weekly standardized counseling for alcohol-related behavior, with assessments of alcohol consumption, mood, sleep and alcohol-craving performed each week.

Inclusion Criteria:

• Men and women over age 18 with alcohol dependence

Exclusion Criteria:

• Currently meets Diagnostic and Statistical Manual 4 Text Revision (DSM-IV-TR) criteria for dependence on illicit substances
• Significant medical disorders that will increase potential risk or interfere with study participation
• Women with childbearing potential who are pregnant, nursing, or refuse to use a reliable method of birth control
• Treatment with an investigational drug in the last month.