Randomized nine months clinical comparison of implantation of Taxol eluting (Taxus Express) and Sirolimus eluting (Cypher Select) stents in non-selected patients with coronary artery disease.

Design:

• Randomized open multicentre trial.

Patients:

• 1800 patients with coronary artery disease scheduled for percutaneous coronary intervention with stent implantation.

Inclusion criteria:

• Patients with coronary artery disease scheduled for percutaneous coronary intervention with stent implantation.
• Signed informed consent.

Exclusion criteria:

• Participation in other stent studies.

Randomization:

• Implantation of Taxus Express og Cypher Select stents.

Primary end-point:

• Combined end-point of cardiac death, new revascularization (PCI or CABG) or myocardial infarction after nine months.

Secondary end-points:

• Total death after nine months
• Cardiac death after nine months
• Myocardial infarction after nine months
• Index vessel myocardial infarction after nine months
• Target lesion revascularization
• Target vessel revascularization
• Stent thrombosis after nine months

End-point evaluation:

• End-points will be adjudicated by an independent end-point committee

Inclusion Criteria:

• Planned implantation of drug eluting stent
• Written informed consent

Exclusion Criteria:

• Planned intervention with other stents than study stents