A Study To Evaluate Formulations And Food Effect On GSK364735 In Healthy Subjects.

A Single Dose, Randomized, 5-Period, Balanced, Crossover Study to Assess the Relative Bioavailability of Three Formulations and Food Effect on GSK364735 and Pharmacokinetics Following a Double Blind, Placebo Controlled, Repeat Dose Administration to Healthy Subjects.

This study is a two-part study. Part one is designed to see how different formulations of GSK364735 are absorbed in the body and To see how food affects how GSK364735 is absorbed in the body. Part two is designed to see how repeat dosing affects how GSK364735 is absorbed in the body.

Inclusion criteria:

• The subject is healthy with no clinically significant problems identified by the physician.
• Females of non-childbearing potential and males surgically sterile or agrees to birth control.
• Body mass Index (BMI) of 19-29.9 (kg/m2).

Exclusion criteria:

• As a result of the physical examination, lab results the Investigator considers the subject unfit for the study.
• Blood pressure and electrocardiogram is not normal
• A history of alcohol or illicit drug abuse.
• Tobacco use within 3 months.
• Positive for Hepatitis B surface antigen, Hepatitis C antibody or HIV antibody.
• Current use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements.
• Has participated in a clinical trial within 30 days prior to the first dose of study medication.
• Donated a pint of blood within a 56 day period.
• History of allergy to study drug.