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This study examined the acceptability and feasibility of introducing a mifepristone-misoprostol regimen of medical abortion into abortion services in two private clinics in Puerto Rico; 2 clinics in Baku, Azerbaijan; 3 clinics in Yerevan, Armenia; and 4 clinics in Mexico City. It was hypothesized that the study regimen would be both acceptable and efficacious.
The study recruited women with pregnancies up to 63 days gestation. Eligible women took 200 mg mifepristone, followed by 800 buccal misoprostol. They later underwent clinic follow-up to determine if their medical abortions were complete. The study assessed the acceptability and feasibility of the above regimen and sought to determine the efficacy and acceptability of buccal administration of misoprostol as well as the acceptability of side effects experienced by women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mifepristone-misoprostol treatment | Other | 200 mg mifepristone followed by 800 mcg buccal misoprostol 24-48 hours after the mifepristone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mifepristone-misoprostol treatment | Drug | 200 mg mifepristone followed by 800 mcg buccal misoprostol 24-48 hours after the mifepristone. |
|
| Measure | Description | Time Frame |
|---|---|---|
| efficacy | 15 days |
| Measure | Description | Time Frame |
|---|---|---|
| acceptability | 15 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hector Diaz Martinez, MD | Clinica de Planificacion Familiar | Principal Investigator |
| Angela Arredondo, MD | Woman's Metropolitan Center | Principal Investigator |
| Beverly Winikoff, MD, MPH | Gynuity Health Projects | Principal Investigator |
| Gulnara Rzaeva, MD | Scientific Research Institute of Obstetrics & Gynecology | Principal Investigator |
| Besti Muradova, MD | Family Planning Center | Principal Investigator |
| Susanna Fildjyan, MD | Institute of Perinatology, Obstetrics and Gynecology | Principal Investigator |
| Armine Harutyunyan, MD | Center for Family Planning and Sexual Health | Principal Investigator |
| Anna Aghajanyan, MD | State Medical University | Principal Investigator |
| Ranulfo Rios, MD | H G Enrique Cabrera | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Family Planning and Sexual Health | Yerevan | Armenia | ||||
| Institute of Perinatology, Obstetrics and Gynecology |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24957534 | Derived | Pena M, Dzuba IG, Smith PS, Mendoza LJ, Bousieguez M, Martinez ML, Polanco RR, Villalon AE, Winikoff B. Efficacy and acceptability of a mifepristone-misoprostol combined regimen for early induced abortion among women in Mexico City. Int J Gynaecol Obstet. 2014 Oct;127(1):82-5. doi: 10.1016/j.ijgo.2014.04.012. Epub 2014 Jun 4. |
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|
| Laura Garcia Martinez, MD | H.M.I Inguaran | Principal Investigator |
| Antonio E Flores, MD | C S Beatriz Velasco Aleman | Principal Investigator |
| Elba Margarita Lugo Hernandez, MD | C S Santa Catarina | Principal Investigator |
| Yerevan |
| Armenia |
| State Medical University | Yerevan | Armenia |
| Family Planning Center | Baku | Azerbaijan |
| Scientific Research Institute of Obstetrics and Gynecology | Baku | Azerbaijan |
| C.S. Beatriz Velasco Aleman | Mexico City | Federal District | Mexico |
| C.S. Santa Catarina | Mexico City | Federal District | Mexico |
| H.G. Enrique Cabrera | Mexico City | Federal District | Mexico |
| H.M.I Inguaran | Mexico City | Federal District | Mexico |
| Clinica de Planificacion Familiar | Lomas Verdes, Bayamon | 00956 | Puerto Rico |
| Woman's Metropolitan Center | San Juan | 00921 | Puerto Rico |