Atazanavir or Lopinavir in HIV Post-exposure Prophylaxis

Comparison of 2 Alternative Antiretroviral Combinations in HIV Post-exposure Prophylaxis: AZT-3TC (Combivir®) + Lopinavir-ritonavir (Kaletra®) Versus AZT-3TC (Combivir®)+ Atazanavir (Reyataz®). Multicentre, Prospective, Randomized, Open Study

The study compares the adherence of 240 HIV-negative subjects randomly assigned to 2 different antiretroviral therapies for 28 days after accidental exposure to HIV.

Inclusion Criteria:

• Age > 18
• HIV exposure requiring prophylaxis under current guidelines

Exclusion Criteria:

• Pregnancy
• Suspected drug resistance in source case
• Contraindications to the study drugs