Study Comparing Arzoxifene With Raloxifene in Women After Menopause With Osteoporosis

The Comparison of the Efficacy and Safety of Arzoxifene Versus Raloxifene in Postmenopausal Women With Osteoporosis

The purpose of this study is to compare the effect of arzoxifene to raloxifene on the bone mineral density (bone strength).

Inclusion Criteria:

• Must have osteoporosis
• Must be between 50 and 75 years old and be able to walk
• Have at least two of your back bones that can be x-rayed
• Have not had a period in at least two years
• Be willing to have blood tests

Exclusion Criteria:

• Have a bone disease other than osteoporosis
• History of estrogen dependent cancer
• History of stroke or certain heart problems
• Possibly have an allergy to raloxifene or arzoxifene
• Have certain abnormal lab values
• History of seizure disorder
• Have unexplained vaginal bleeding or an abnormal pap smear