Short- and Long Term Growth in Children With Asthma

Short- and Long Term Growth in Children With Asthma Treated With Budesonide or Montelukast

The purpose of this study is to assess if treatment with budesonide 200 microgram per day affects short- or long term growth in children with asthma

When children with asthma are treated with inhaled corticosteroids there is a risk of systemic adverse events such as growth suppression. It has been reported that treatment with budesonide 200 microgram per day does not affect short term growth in children with asthma. The aim of the present study is to assess if an unaffected short term growth means that also long term growth will be unaffected.

Short and long term growth in asthmatic children treated with budesonide will be compared with the growth in asthmatic children treated with montelukast.

Inclusion Criteria:

• age 6-11,
• prepubertal,
• asthma,
• normal weight and height,
• informed consent

Exclusion Criteria:

• treatment with systemic/inhaled/intranasal corticosteroids within the last week,
• major surgery within 4 weeks,
• usage of drugs that significantly inhibit CYP3A4