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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA016237 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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This five-year study examines the benefits of methadone maintenance treatment initiated in prison and continued in the community to male offenders who were previously, but not currently, heroin-dependent. It is anticipated that such prisoners will have more favorable outcomes in the year following release with regard to drug abuse, crime, and HIV risk behavior than either prisoners who receive counseling only or begin initiation of methadone maintenance in the community
Most prisoners with histories of pre-incarceration heroin addiction do not receive treatment while incarcerated or upon release. Effective treatment for such prisoners is urgently needed because rapid relapse typically follows release. Relapse is associated with increased risk for HIV, overdose death, criminal activity, and reincarceration. Other than three studies of methadone maintenance with short-term jail inmates, the only study of longer-term inmates who were previously, but not currently, heroin-dependent was the investigator's pilot study with pre-release inmates. Based on that pilot study, which found that initiating maintenance treatment is feasible and facilitates post-release treatment entry, the present study provides a more rigorous examination of this unique treatment approach.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 3 | Experimental |
| |
| 1 | Active Comparator |
| |
| 2 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Counseling Only | Other | Counseling only in prison, with passive referral to drug abuse treatment upon release |
|
| Measure | Description | Time Frame |
|---|---|---|
| Treatment Retention in the Community | days in community treatment | one year post prison release |
| Heroin Use | opioid urine test results-percent of participants who were opioid-positive | results at one year post prison release |
| Cocaine Use | cocaine urine test results-percent of participants testing positive for cocaine | one year post prison release |
| HIV-risk Behaviors | one year | |
| Criminal Activity | self reported days of criminal activity | one year post prison release |
| Measure | Description | Time Frame |
|---|---|---|
| Employment | number of days employed, past 30 days-self report, assessed one year post-prison release | one year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Timothy W Kinlock, Ph.D. | Friends Research Institute, Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Metropolitan Transition Center | Baltimore | Maryland | 21201 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Kinlock TW, Schwartz RP, Gordon MS. The significance of interagency collaboration in developing opioid agonist programs for inmates. Corrections Compendium 30(3)6-9,28-30,2005. | ||
| 17628351 | Result | Kinlock TW, Gordon MS, Schwartz RP, O'Grady K, Fitzgerald TT, Wilson M. A randomized clinical trial of methadone maintenance for prisoners: results at 1-month post-release. Drug Alcohol Depend. 2007 Dec 1;91(2-3):220-7. doi: 10.1016/j.drugalcdep.2007.05.022. Epub 2007 Jul 12. | |
| 18612373 |
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See above
See publication in Journal of Substance Abuse Treatment (2009), 37, 277-285.In summary, participants were recruited between September 2003 and June 2005 from male prisoners in a Baltimore pre-release facility. They had to have met criteria for methadone maintenance treatment in the year prior to incarceration.
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| ID | Title | Description |
|---|---|---|
| FG000 | 1 Counseling Only in Prison | Counseling Only : Counseling only in prison, with passive referral to drug abuse treatment upon release |
| FG001 | 2 Counseling Only in Prison, With Initiation of Methadone Main | Counseling + Transfer : Counseling only in prison, with opportunity to enter methadone maintenance upon release |
| FG002 | 3 Counseling and Methadone Maintenance in Prison, With Continu | Counseling + Methadone : Counseling and methadone maintenance in prison, with opportunity to continue that treatment upon release |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
|
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| ID | Title | Description |
|---|---|---|
| BG000 | 1 Counseling Only in Prison | Counseling Only : Counseling only in prison, with passive referral to drug abuse treatment upon release |
| BG001 | 2 Counseling Only in Prison, With Initiation of Methadone Main |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Treatment Retention in the Community | days in community treatment | Posted | Mean | Standard Deviation | Days in community treatment | one year post prison release |
|
at any time up to one year after release from prison
The first series of results reports the number and percent of participants by treatment condition who died. The second series involve hospitalizations-the number of participants in each condition that had one or more hospitalizations and the number of events. Other (non-serious) Adverse Events were not collected/assessed..
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | 1 Counseling Only in Prison | Counseling Only : Counseling only in prison, with passive referral to drug abuse treatment upon release |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Death | Injury, poisoning and procedural complications | Systematic Assessment |
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See 2009 manuscript published in the Journal of Substance Abuse Treatment for the a discussion of study limitations. The study was conducted only on males from Baltimore. For results regarding HIV risk behaviors see manuscript by Wilson et. al.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Timothy Kinlock | Friends Research Institute | (410) 837-3977 | 224 | tkinlock@friendsresearch.org |
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| ID | Term |
|---|---|
| D006556 | Heroin Dependence |
| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| D000079524 | Narcotic-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
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| ID | Term |
|---|---|
| D003376 | Counseling |
| D036801 | Parturition |
| D008691 | Methadone |
| ID | Term |
|---|---|
| D008605 | Mental Health Services |
| D004191 | Behavioral Disciplines and Activities |
| D003153 | Community Health Services |
| D006296 | Health Services |
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| Counseling + Transfer | Drug | Counseling only in prison, with opportunity to enter methadone maintenance upon release |
|
| Counseling + Methadone | Drug | Counseling and methadone maintenance in prison, with opportunity to continue that treatment upon release |
|
| Result |
| Kinlock TW, Gordon MS, Schwartz RP, O'Grady KE. A Study of Methadone Maintenance For Male Prisoners: 3-Month Postrelease Outcomes. Crim Justice Behav. 2008;35(1):34-47. doi: 10.1177/0093854807309111. |
| 18855822 | Result | Gordon MS, Kinlock TW, Schwartz RP, O'Grady KE. A randomized clinical trial of methadone maintenance for prisoners: findings at 6 months post-release. Addiction. 2008 Aug;103(8):1333-42. doi: 10.1111/j.1360-0443.2008.002238.x. |
| 19339140 | Result | Kinlock TW, Gordon MS, Schwartz RP, Fitzgerald TT, O'Grady KE. A randomized clinical trial of methadone maintenance for prisoners: results at 12 months postrelease. J Subst Abuse Treat. 2009 Oct;37(3):277-85. doi: 10.1016/j.jsat.2009.03.002. Epub 2009 Mar 31. |
| 22882399 | Result | Wilson ME, Kinlock TW, Gordon MS, O'Grady KE, Schwartz RP. Postprison release HIV-risk behaviors in a randomized trial of methadone treatment for prisoners. Am J Addict. 2012 Sep-Oct;21(5):476-87. doi: 10.1111/j.1521-0391.2012.00250.x. |
| 25580067 | Result | Kinlock TW, Gordon MS, Schwartz RP, O'Grady KE. Individual Patient and Program Factors Related to Prison and Community Treatment Completion in Prison-Initiated Methadone Maintenance Treatment. J Offender Rehabil. 2013 Oct;52(8):509-528. doi: 10.1080/10509674.2013.782936. |
Counseling + Transfer : Counseling only in prison, with opportunity to enter methadone maintenance upon release
| BG002 | 3 Counseling and Methadone Maintenance in Prison, With Continu | Counseling + Methadone : Counseling and methadone maintenance in prison, with opportunity to continue that treatment upon release |
| BG003 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
Counseling + Methadone : Counseling and methadone maintenance in prison, with opportunity to continue that treatment upon release |
|
|
| Primary | Heroin Use | opioid urine test results-percent of participants who were opioid-positive | Includes participants who provided urine samples at the time their 1-year post-prison release assessment was due-excludes those assessed later or reincarcerated | Posted | Number | % participants opioid positive | results at one year post prison release |
|
|
|
| Primary | Cocaine Use | cocaine urine test results-percent of participants testing positive for cocaine | Includes participants who provided urine samples at the time their 1-year post-prison release assessment was due, excludes those assessed later or reincarcerated | Posted | Number | percent cocaine positive participants | one year post prison release |
|
|
|
| Primary | HIV-risk Behaviors | Not Posted | one year |
| Primary | Criminal Activity | self reported days of criminal activity | Posted | Mean | Standard Deviation | number of days | one year post prison release |
|
|
|
| Secondary | Employment | number of days employed, past 30 days-self report, assessed one year post-prison release | Posted | Mean | Standard Deviation | number of days employed, past 30 | one year |
|
|
|
| 15 |
| 70 |
| 0 |
| 0 |
| EG001 | 2 Counseling Only in Prison, With Initiation of Methadone Main | Counseling + Transfer : Counseling only in prison, with opportunity to enter methadone maintenance upon release | 6 | 70 | 0 | 0 |
| EG002 | 3 Counseling and Methadone Maintenance in Prison, With Continu | Counseling + Methadone : Counseling and methadone maintenance in prison, with opportunity to continue that treatment upon release | 16 | 71 | 0 | 0 |
| hospitalizations | General disorders | Systematic Assessment |
|
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| D001523 | Mental Disorders |
| D005159 | Health Care Facilities Workforce and Services |
| D011247 | Pregnancy |
| D012098 | Reproduction |
| D055703 | Reproductive Physiological Phenomena |
| D012101 | Reproductive and Urinary Physiological Phenomena |
| D007659 | Ketones |
| D009930 | Organic Chemicals |