Study Evaluating the Pharmacokinetics of Tigecycline in Human Bone

An Open-Label, Multiple-Dose Study of the Pharmacokinetics of Tigecycline in Human Bone

Study to examine the concentration of the study drug, tigecycline, in human bone samples following the administration of multiple doses.

Inclusion:

• Men and nonlactating and nonpregnant women greater than or equal to 18 years of age.
• Healthy as determined by the investigator on the basis of medical history, physical examination, vital signs, and 12-lead electrocardiogram (ECG).
• Have a high probability for compliance with and completion of the study.

Exclusion:

• Subjects with chronic osteomyelitis.
• Subjects who have known or suspected hypersensitivity to tigecycline or other tetracyclines.
• Involvement in other investigational studies of any type within 30 days before test article administration.