Investigation of Early Hormonotherapy Efficacy of Prostate Cancer

Investigation of Early Hormonotherapy Efficacy of High Risk Patients for Progression of Prostate Cancer After Radical Prostatectomy

The purpose of this study is to determine whether early hormonotherapy is effective in the treatment of high risk prostate cancer patients after radical prostatectomy.

The primary purpose of this study is to evaluate the hypothesis, that early administration of adjuvant hormonotherapy (triptorelin) can prolong survival data for high risk patients. Control group (randomised study) will be treated with hormonotherapy, when PSA recidive appear (on demand treatment). Secondary purposes will be to compare PSA dinamics and quality of life data in the groups.

Inclusion Criteria:

• preoperative PSA>20ng/ml
• postoperative PSA >0.2 ng/ml
• Gleason > 7
• pT3b
• signated infomed consent

Exclusion Criteria:

• neoadjuvant hormonaltherapy before RP
• R1 RP
• N+ RP
• unstable cncomitant conditions