The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning

Lead poisoning remains a common disease among children despite successful public health efforts that reduced its prevalence.Our study was designed to test the hypothesis that lead-poisoning children (BLLs:100-440µg/L) who were given DMSA and multi-nutrients would have a greater fall than children of other groups at 12 weeks of follow-up.

Inclusion Criteria:

• Initial BLLs 100-440µg/L
• Age 3-6y
• No more than two main residences
• House cleaned (no lead contaminated)
• Normal intake history and physical

Exclusion Criteria:

• Chelation in the past 12 weeks
• Concomitant Fe deficiency(ferritin<16ng/ml)
• Hemoglobin<10.5g/dL
• Medications affecting mineral metabolism