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The purpose of this study is to test if recombinant follicle stimulating hormone (rFSH) given in individual doses, according to a nomogram we have constructed based on our results from a previous study, results in more patients maturing 2-3 follicles compared to standard dose.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| "Individual" or "standard" rFSH dose | Active Comparator | Patients were randomized to recieve "individual" (50, 75 or 100 IU/day) or "standard" (75 IU/day) rFSh dose. The individual dose was prescribed according to a dosage nomogram based on the patient's body weight (kg) and the total antral follicle count (Freiesleben NC et al., RBMOnline 2009;17:632-64). |
|
| "Standard" rFSH dose | Active Comparator | "Standard" dose of rFSH |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rFSH drug dose | Drug | "Individual" rFSH dose (50, 75 or 100 IU rFSH/day) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of mature follicles in the study and control group. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of cycles where the rFSH dose is changed. | ||
| Number of cycles cancelled or converted to in vitro fertilisation. | ||
| Pregnancy rate. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anders N Andersen, Professor,MD | The Fertility Clinic, dep.4071, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen East, Denmark | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Fertility Clinic, dep.4071, Copenhagen University Hospital, Rigshospitalet | Copenhagen East | 2100 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19602518 | Background | la Cour Freiesleben N, Lossl K, Bogstad J, Bredkjaer HE, Toft B, Rosendahl M, Loft A, Bangsboll S, Pinborg A, Nyboe Andersen A. Individual versus standard dose of rFSH in a mild stimulation protocol for intrauterine insemination: a randomized study. Hum Reprod. 2009 Oct;24(10):2523-30. doi: 10.1093/humrep/dep239. Epub 2009 Jul 14. | |
| 20303323 |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| "Standard" rFSH dose | Drug | "Standard" rFSH dose was 75 IU/day |
|
| October 2008 |
| Freiesleben Nl, Rosendahl M, Johannsen TH, Lossl K, Loft A, Bangsboll S, Friis-Hansen L, Pinborg A, Andersen AN. Prospective investigation of serum anti-Mullerian hormone concentration in ovulatory intrauterine insemination patients: a preliminary study. Reprod Biomed Online. 2010 May;20(5):582-7. doi: 10.1016/j.rbmo.2010.02.007. Epub 2010 Feb 12. |