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USPIO contrast enhancement results from intracellular trapping of the iron particles in reactive cells, especially macrophages. 17FDG-PET studies have demonstrated that macrophages are present in spine infectious diseases but are absent in spine degenerative diseases. The aim of this work is to compare the enhancement induced by CLIAVIST in both diseases. The absence of macrophages in degenerative lesions should help to differentiate them from infectious lesions, who should present contrast enhancement in relation to the presence of macrophages.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cliavist | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cliavist | Drug | Injection of 0,9 mL (weight < 60kg) or 1,4 mL (weight > 60kg) of Cliavist (ferucarbotran) by direct intraveinous way, 48 h following the MRI done with gadolinium. |
| Measure | Description | Time Frame |
|---|---|---|
| First MRI: performed immediately after gadolinium administration | immediately after gadolinium administration | |
| Second MRI: performed 24 hours after cliavist administration | 24 hours after cliavist administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jean-Louis Dietemann, MD | Contact | (33) 3 88127888 | jean-louis.dietemann@chru-strasbourg.fr | |
| Stéphane Kremer, MD | Contact | (33) 3 88127888 | stephane.kremer@chru-strasbourg.fr |
| Name | Affiliation | Role |
|---|---|---|
| Jean-Louis Dietemann, MD | Hôpitaux Universitaires de Strasbourg | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Neuroradiologie - Hôpital Central | Not yet recruiting | Nancy | 54035 | France |
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| ID | Term |
|---|---|
| D007239 | Infections |
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| Nouvel Hôpital Civil | Not yet recruiting | Strasbourg | 67091 | France |
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| Service de Radiologie 2 - Hôpital de Hautepierre | Recruiting | Strasbourg | 67098 | France |
|
| Service de Rhumatologie - Hôpital de Hautepierre | Not yet recruiting | Strasbourg | 67098 | France |
|