The purpose of this study is to measure the antimicrobial effects of Arestin in subjects with moderate to advanced periodontal disease

Inclusion Criteria:

• Generalized moderate to advanced chronic periodontitis, five sites with probing depths of >5 mm in 5 non-adjacent interproximal spaces, excluding the distal of terminal teeth, at least 16 teeth excluding 3rd molars and implants

Exclusion Criteria:

• Allergy to tetracycline
• Subjects with aggressive periodontitis
• Acute necrotizing ulcerative gingivitis, or gross decay
• Systemic conditions which could influence the course of periodontal disease (i.e, diabetes, autoimmune disease, etc)
• Individuals requiring prophylactic antibiotics
• Any periodontal therapy within the previous 3 months (excluding maintenance therapy)
• Systemic or local antibiotic therapy within three months