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To evaluate the efficacy of oral colchicine combined with intraoperative infusion of dexamethasone, low molecular weight heparin and 5-FU during vitrectomy for management of established proliferative vitreoretinopathy (PVR)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator |
| |
| 2 | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oral colchicine, dexamethasone, low molecular weight heparin, 5-FU | Drug |
| ||
| placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Retinal reattachment rate |
| Measure | Description | Time Frame |
|---|---|---|
| PVR recurrence, | ||
| macular pucker, | ||
| reoperation, |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hamid Ahmadieh, MD | Contact | +98 21 22585952 | hahmadieh@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Hamid Ahmadieh, MD | Ophthalmic Research Center of Shaheed Beheshti Medical University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hamid Ahmadieh, MD | Recruiting | Tehran | Tehran Province | 16666 | Iran |
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| Drug |
|
| ocular hypotony, |
| visual acuity |
| ID | Term |
|---|---|
| D018630 | Vitreoretinopathy, Proliferative |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D003078 | Colchicine |
| D003907 | Dexamethasone |
| D006495 | Heparin, Low-Molecular-Weight |
| D005472 | Fluorouracil |
| ID | Term |
|---|---|
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D006493 | Heparin |
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
| D014498 | Uracil |
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
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