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The purpose of the study is to seek if there is difference to state glucose level in 80-120mg/dl or 200mg/dl in patients submitted to open heart surgery
Hyperglycaemia in the intensive care unit and perioperative period has been accused to be one of the causes of worse clinical outcome. It is known that in open heart surgeries the glucose level must be set less than 200mg/dl, but new trials had set the glucose level lower than that: 140mg/dl in some studies and even lower (80-110mg/dl). Our trial had the intention to seek if there is difference setting glucose level in 2 different ones would modifies clinical outcome.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| human regular insulin | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of intubation | ||
| ICU length | ||
| Blood transfusion | ||
| Infection rate | ||
| Renal dysfunction | ||
| Neurological dysfunction | ||
| Hospital length | ||
| Mortality |
| Measure | Description | Time Frame |
|---|---|---|
| Length of surgery | ||
| Length of cardiopulmonary bypass | ||
| Physical status |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jose O Costa Auler Junior, Professor | Heart instutute, Hospital of Clinics, São Paulo University Medical School | Principal Investigator |
| Raquel PC Chan | Heart Institute, Hospital of Clinics, São Paulo University Medical School | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heart Institute, Hospital of Clinics, São Paulo University Medical School | São Paulo | São Paulo | 05403-000 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11794168 | Result | van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67. doi: 10.1056/NEJMoa011300. | |
| 9033300 | Result | Zerr KJ, Furnary AP, Grunkemeier GL, Bookin S, Kanhere V, Starr A. Glucose control lowers the risk of wound infection in diabetics after open heart operations. Ann Thorac Surg. 1997 Feb;63(2):356-61. doi: 10.1016/s0003-4975(96)01044-2. |
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| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D018754 | Ventricular Dysfunction |
| D006943 | Hyperglycemia |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D007328 | Insulin |
| ID | Term |
|---|---|
| D011384 | Proinsulin |
| D061385 | Insulins |
| D010187 | Pancreatic Hormones |
| D036361 | Peptide Hormones |
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| EuroSCORE |
| Parsonnet |
| Canadian Multicenter index |
| 19142552 | Derived | Chan RP, Galas FR, Hajjar LA, Bello CN, Piccioni MA, Auler JO Jr. Intensive perioperative glucose control does not improve outcomes of patients submitted to open-heart surgery: a randomized controlled trial. Clinics (Sao Paulo). 2009;64(1):51-60. doi: 10.1590/s1807-59322009000100010. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D006728 |
| Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |