Chlorhydrate of Ropivacaine and Breast Cancer Surgery

Efficacy of Infiltration of Chlorhydrate of Ropivacaine in the Prevention of Chronic Breast Pain After Surgery for Breast Cancer.

The aim of the study is to evaluate the effect of local anesthetic (chlorhydrate of ropivacaine) to prevent chronic pain after breast surgery for cancer.

An estimated 20-65% of women treated with breast surgery for breast cancer experience chronic pain in the treated breast. Patients will be randomize between: infiltration with chlorhydrate of ropivacaine at the time of breast surgery for cancer versus placebo.Intra-operative analgesia will be standardized as well as peri-operative pain management.

Inclusion Criteria:

• Breast cancer patients treated by conservative surgery with axillary node dissection or treated by mastectomy with or without axillary node dissection or sentinel lymph node biopsy.
• ASA physical status 1, 2 or 3
• With a minimum life expectancy of 2 years
• Written informed consent

Exclusion Criteria:

• Any previous cancer other than breast cancer
• Allergies to local anesthesic and morphine
• Reported history of drug
• Pregnancy
• Homolateral breast surgery during the last 3 years
• Analgesic use pre-operatively
• Renal, pulmonary or liver major dysfunction
• Active malignant disease
• Unable to follow the protocol for any reason