Azithromycin Plus Chloroquine Versus Mefloquine In the Treatment of Uncomplicated P. Falciparum Malaria.

A Phase 3, Randomized, Open-Label, Comparative Trial Of Azithromycin Plus Chloroquine Versus Mefloquine For The Treatment Of Uncomplicated Plasmodium Falciparum Malaria In Africa

To compare Azithromycin plus Chloroquine versus Mefloquine to treat uncomplicated plasmodium falciparum malaria.

Inclusion Criteria:

• Females and males 18 years of age and older with uncomplicated, symptomatic malaria as as indicated by the presence of both of the following:
• Blood smears positive for Plasmodium falciparum asexual parasitemia between 1000 -100,000 parasites
• Documented fever (38.5 C/101.3 F rectal or tympanic; 37.5 C/99.5 F axillary or 38 C/100.4 F oral) or history of fever (as reported by subject) within the prior 24 hours.

Exclusion Criteria:

• Severe or complicated malaria.
• Pregnant or breast-feeding women.