A Study of the Alternative Administration of Ixabepilone and Vinflunine

A Study of the Alternating Administration of Ixabepilone and Vinflunine Every Three Weeks in Patients With Advanced Cancer

The purpose of the study is to test how vinflunine interacts with ixabepilone in the human body.

Inclusion Criteria:

• ECOG status of 0-1

Exclusion Criteria:

• Inability to tolerate venous access
• Brain mets
• Severe nerve damage
• ANC <2,000/mm3
• Platelets <100K
• Bilirubin >= 1.5 times the IULN
• ALT/AST >= 2.5 times the IULN
• Creatinine <50 mL/min
• Prior treatment with vinflunine and/or ixabepilone
• Strong use of CYPP450 drugs