Inclusion Criteria:
- Patients with proven mild to moderate Hypertension.
- Patients must have left ventricular mass index > 130g/m2 in men, > 100g/m2 in women, as evidenced by echocardiography before inclusion.
- Newly diagnosed "naïve" hypertensive patients (no prior treatment for hypertension). OR,
- Patients who were receiving antihypertensive agents (maximum two agents including one diuretic) with blood pressure targets achieved, yet, in the investigator's opinion, those patients would benefit more from switching to the study medication. These patients will undergo a wash out period for not less than 7 days prior to enrollment.
Exclusion Criteria:
- Severe hypertension (Systolic BP ≥ 180 mm Hg or Diastolic BP ≥ 110 mm Hg).
- Patients with left ventricular ejection fraction < 45%.
- Patients with severe left ventricular hypertrophy.
- Patients with known secondary hypertension (for another cause other than type 2 Diabetes Mellitus).
- Diabetic patients with HbA1c > 10%.
- Significant chronic renal impairment (Serum creatinine > 2.0 mg/dL).
- Significant liver disease as shown by SGPT/SGOT (ALT/AST) > 2.5 times the upper limit of the normal range.
- Currently pregnant or lactating females.
- Women of childbearing potential not protected by effective contraceptive method of birth control and/or who are unwilling or unable to be tested for pregnancy.
- Any patient who is in need for a combination antihypertensive therapy from the start (from the medical point of view of his/her physician).
- Known hypersensitivity to irbesartan, other ARBs(Angiotensin Receptor Blockers), hydrochlorothiazide, or other thiazide diuretics.
- Patients with malignancy during the past 5 years, known collagen disease or severe cardiac, cerebrovascular or gastric disease.
The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.