Safety and Effects of Ramipril Combined With Candesartan

Cardiovascular and Metabolic Effects of Combination Therapy With Ramipril and Candesartan In Hypertensive Patients

we hypothesized that combination therapy has additive beneficial effects to improve endothelial dysfunction and adipocytokine profiles in patients with hypertension.

Forty patients will be given ramipril 10 mg and placebo, ramipril 10 mg and candesartan 16 mg, or candesartan 16 mg and placebo daily in a randomized, double-blind, placebo-controlled cross-over trial with three treatment arms and two washout periods (each 2 months).

Inclusion Criteria:

• patients with mild to moderate hypertension

Exclusion Criteria:

• We will exclude patients with severe hypertension, unstable angina, acute myocardial infarction, or renal insufficiency.