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| ID | Type | Description | Link |
|---|---|---|---|
| PV1087 |
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| Name | Class |
|---|---|
| BASF | INDUSTRY |
This study will examine the the efficiency fo absorption of major plant pigments, carotenoids, (lutein, beta-carotene and lycopene)and will measure the biological functions of carotenoids in healthy women in response to an 8-week period of carotenoid supplementation.
The antioxidant capacity (in both the aqueous and lipid compartments), DNA oxidation (single cell gel electrophoresis), Insulin-like Growth Factor (IGF-1), Insulin-like Growth Factor Binding Protein-3 (IGFBP-3), (gene expression profile (high-density filter-based cDNA microarrays), lipid peroxidation (MDA analysis and Isoprostane determination), and antioxidant nutrient levels (carotenoids, tocopherols, ascorbic acid and uric acid) in the circulation will be measured every other week throughout the study period.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mixed carotenoids | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| DNA damage | ||
| plasma carotenoid concentrations |
| Measure | Description | Time Frame |
|---|---|---|
| lipid peroxidation | ||
| Total antioxidant capacity |
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| Name | Affiliation | Role |
|---|---|---|
| Kyung-Jin Yeum, PhD | Tufts Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jean Mayer USDA-Human Nutrition Research Center on Aging, Tufts University | Boston | Massachusetts | 02111 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16400064 | Result | Zhao X, Aldini G, Johnson EJ, Rasmussen H, Kraemer K, Woolf H, Musaeus N, Krinsky NI, Russell RM, Yeum KJ. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. Am J Clin Nutr. 2006 Jan;83(1):163-9. doi: 10.1093/ajcn/83.1.163. |
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|---|---|
| Article | View source |
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