Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.

Changes of the Neuronal Activity in the Subthalamic Nucleus Under Propofol Sedation During Stereotactic Electrode Implantation.

The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.

Deep Brain Stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who have to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the Basal Ganglia.

The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to propofol sedation. Electrical activity of single neurons will be recorded before and after sedation.

Inclusion Criteria:

• Candidate for Deep Brain Stimulation Surgery.
• Informed concent obtained.

Exclusion Criteria:

• Suspected difficult intubation (by history or physical examination).
• Allergy to Propofol, eggs or soy-beans.
• History of sleep apnea syndrome.