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| Name | Class |
|---|---|
| Norwegian Food Research | UNKNOWN |
| Gilde | OTHER |
| Norwegian Foundation for Health and Rehabilitation | OTHER |
| Sykehuset Innlandet HF |
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This randomised, double blind, cross-over study compares the effect (symptoms, fecal bacterial growth, gas production) of three weeks' treatment with lactobacillus plantarum MF 1298 with placebo in patients with irritable bowel syndrome. The results are related to dietary habits, food intolerance and food allergy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| placebo followed by probiotic | Experimental | placebo, then washout period, then Lactobacillus plantarum MF1298 |
|
| probiotic followed by placebo | Experimental | Lactobacillus plantarum MF1298, then washout period, then placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| placebo followed by Lactobacillus plantarum MF 1298 | Dietary Supplement | placebo during 3 weeks, washout period 4 weeks, Lactobacillus plantarum MF1298 during 3 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Satisfactory relief of abdominal symptoms | relief of symptoms recorded on diary cards | 11 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Graded measurement of abdominal symptoms | IBS sum score | 11 weeks |
| Fecal bacterial count | 11 weeks | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Per G Farup, PhD | Norwegian University of Science and Technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Innlandet Hospital HF | Gjøvik | Oppland | N-2819 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20144246 | Result | Ligaarden SC, Axelsson L, Naterstad K, Lydersen S, Farup PG. A candidate probiotic with unfavourable effects in subjects with irritable bowel syndrome: a randomised controlled trial. BMC Gastroenterol. 2010 Feb 10;10:16. doi: 10.1186/1471-230X-10-16. | |
| 22899904 | Result | Farup PG, Jacobsen M, Ligaarden SC, Rudi K. Probiotics, symptoms, and gut microbiota: what are the relations? A randomized controlled trial in subjects with irritable bowel syndrome. Gastroenterol Res Pract. 2012;2012:214102. doi: 10.1155/2012/214102. Epub 2012 Jul 31. |
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| ID | Term |
|---|---|
| D005767 | Gastrointestinal Diseases |
| D043183 | Irritable Bowel Syndrome |
| ID | Term |
|---|---|
| D004066 | Digestive System Diseases |
| D003109 | Colonic Diseases, Functional |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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| OTHER |
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| Lactobacillus plantarum MF1298 followed by placebo | Dietary Supplement | Lactobacillus plantarum MF1298 during 3 weeks, washout period 4 weeks, placebo during 3 weeks |
|
|
| Abdominal gas |
| 11 weeks |
| Immunological parameters | 11 weeks |
| D019602 |
| Food and Beverages |