A Trial Evaluating the Clinical Applicability, Correlation, and Modeling of Cardiac CT Using 64 Detector Row VCT

An Open-label, Non-randomized, Multi-center Trial Evaluating the Clinical Applicability, Correlation, and Modeling of Cardiac CT Using 64 Detector Row VCT

To compare computed tomography (CT) images (pictures) of the coronary arteries using the General Electric (GE) LightSpeed VCT scanner with x-ray coronary angiography in patients referred for an x-ray coronary angiography.

Inclusion Criteria:

• Patients scheduled for elective diagnostic catheterization OR
• Elective diagnostic catheterization has been performed within the past 2 weeks but no less than 24 hours prior to the coronary CTA procedure with no intervention performed or change of the patient clinical status.
• Age ≥18 years but ≤75 years.

Exclusion Criteria:

• Prior coronary stent implantation

• Prior coronary artery bypass grafting or other heart surgery

• Prior pacemaker or internal defibrillator lead implantation

• Prior artificial heart valve

• Biochemical renal insufficiency (CrSerum > 1.6) or on dialysis

• Resting HR > 100 at the time of enrollment

• Contraindication to β-blockade or calcium channel blocker

  • NYHA-IV
  • High-grade atrioventricular (AV) block
  • Systolic blood pressure <90 mm Hg
  • Severe asthma or active bronchospasm and/or chronic obstructive pulmonary disease

• Atrial fibrillation

• Inability to provide informed consent

• Evidence of ongoing or active clinical instability

  • Acute chest pain (sudden onset)
  • Acute myocardial infarction
  • Cardiac shock
  • Acute pulmonary edema