Lantus in Prediabetes

Assessment of Safety and Tolerability of Lantus® (Insulin Glargine) in Subjects With Impaired Fasting Glucose (IFG) or Impaired Glucose Tolerance (IGT)

To assess the safety, tolerability, and efficacy of Lantus® (insulin glargine) in prediabetes (IFG or IGT).

Inclusion Criteria:

• Hyperglycemia (either IGT , IFG, or untreated type 2 diabetes)
• HbA1c < 7.0%
• BMI < 40kg/m2
• Able to perform moderate stationary bicycle exercise

Exclusion Criteria:

• Chronic pharmacologic treatment for hyperglycemia, past or present
• CAD
• serum creatinine > 2.0mg/dL
• BP > 180/105
• History of hypoglycemia unawareness