Efficacy of Topical Cyclosporin for Ocular Rosacea

Efficacy of Topical Cyclosporin 0.05% for the Treatment of Ocular Rosacea

The purpose of this study is to determine whether Restasis (topical cyclosporin) is effective in the treatment of ocular rosacea

The study is designed to compare the efficacy of topical cyclosporin (Restasis) with that of Refresh Endura for the treatment of the signs and symptoms of ocular rosacea in patients presently controlled on topical corticosteroids

Inclusion Criteria:

• Patient at least 18 years old, but younger than 65
• Diagnosis of acne rosacea
• Active ocular rosacea based on lid findings of meibomian gland dysfunction with lid telangiectasia and hyperemia of at least 2+
• Schirmers test of greater than 5mm in at least 1 eye
• If patient currently using lid hygiene must maintain regimen during study
• Stop oral antibiotics at least 4 weeks prior

Exclusion Criteria:

• Use of topical cyclosporin within last 90 days
• Visual acuity of 20/100 or better in both eyes
• Pregnant or lactating females
• Active ocular infection
• Scarring of central cornea
• Eyelid defects,abnormal lid positioning or lagophthalmos
• Flax seed or Fish oil supplements within last 30 days