An Open, Randomized Pilot Study to Evaluate the Use of Basiliximab With an Optimized Cyclosporine Dosing on Renal Function in "de Novo" Liver Transplantation.

An Open, Randomized Pilot Study to Evaluate the Use of Basiliximab With an Optimized Cyclosporine Dosing on Renal Function in "de Novo" Liver Transplantation.

The objectives of the study are:To compare the renal function of a quadruple immunosuppressive regimen (including basiliximab in combination with an optimized cyclosporine dose during the first weeks post-transplantation, mycophenolate mofetil and corticosteroids) versus a standard triple therapy regimen (including cyclosporine standard dose, mycophenolate mofetil and corticosteroids)

Inclusion Criteria

• First cadaveric liver transplant
• ABO identical or compatible graft

Exclusion Criteria

• Multiple organ transplant
• renal impairment defined as glomerular filtration rate (GFR) < 30 ml/min
• Fulminant liver failure

Other protocol-defined exclusion criteria may apply.