Fatigue in Multiple Sclerosis: Evaluated With 3 MRI and Transcranial Magnetic Stimulation

Fatigue in Multiple Sclerosis: Evaluated With 3 Tesla MRI and Transcranial Magnetic Stimulation

The purpose of this study is to investigate fatigue in patients with multiple sclerosis (MS) and to determine the correlation between the symptom and cerebral changes.

Only recruiting from:

Department of Neurology, Aarhus University Hospital, Denmark

Inclusion Criteria:

• Relapsing remitting-multiple sclerosis (RR-MS) according to Poser criteria
• EDSS: max 3.5
• Right handed
• Normal function of the right hand

Exclusion Criteria:

• Disease interfering with MS
• Known dementia
• Drug or alcohol abuse
• Treatment with psychoactive drugs within one week before study entry
• Major changes of medical treatment within 3 weeks before study entry
• Attack within 4 weeks before study entry
• Pregnancy
• Conditions interfering with 3,4-diaminopyridine treatment
• Conditions interfering with MRI
• Conditions interfering with transcranial magnetic stimulation