A Phase II Trial Neoadjuvant Paclitaxel and Cisplatin in Patients With Locally Advanced Head and Neck Cancer

A Phase II Trial Neoadjuvant Paclitaxel and Cisplatin in Patients With Locally Advanced Head and Neck Cancer

The purpose of this clinical research study is to learn if a paclitaxel-cisplatin combination regimen given in the neoadjuvant setting is active in locally advanced head and neck cancer. the safety of this treatment will also be studied.

Inclusion Criteria:

• Locally advanced, Stage II-IV (except M1), hand and neck cancer
• > = 1 measurable lesion
• not been previously treated for head and neck cancer

Exclusion Criteria:

• history of another malignancy
• organ allografts
• pre-exiting neuropathy > = CTC grade 2