Maxillary Sinus Irrigation in the Management of Chronic Rhinosinusitis

Effectiveness of Maxillary Sinus Saline Irrigation in Conjunction With Systemic Antibiotic Therapy Versus Systemic Antibiotic Therapy Alone in the Management of Chronic Rhinosinusitis, a Prospective Randomized Controlled Trial

The purpose of this study is to evaluate the effectiveness of maxillary sinus saline irrigation in conjunction with systemic antibiotic therapy versus systemic antibiotic therapy alone in the management of chronic rhinosinusitis, a prospective randomized controlled trial.

Effectiveness of maxillary sinus saline irrigation in conjunction with systemic antibiotic therapy versus systemic antibiotic therapy alone in the management of chronic rhinosinusitis. A prospective randomized controlled trial is being conducted in Carmel Medical Center, Haifa, Israel. Patients are being randomized into one of two arms. One arm receives sinus irrigation with saline in conjunction with IV antibiotics, the control arm receives the same regimen of IV antibiotics without the sinus irrigation. Quality of life, CT scans and nasal endoscopy parameters are collected before and after treatment.

Inclusion Criteria:

• Chronic (over 3 months) maxillary and ethmoidal rhinosinusitis (verified by a CT scan)
• Over 18 years of age
• Signed informed consent
• Not participating in another clinical study

Exclusion criteria:

• A previous sinonasal surgery or craniofacial trauma
• Isolated frontal or sphenoidal sinusitis
• Immunosuppressed (diabetes, cancer, etc.)
• Craniofacial deformity
• Allergic fungal sinusitis
• Nasal polyposis
• Rhinosinusitis of dental origin
• Bleeding tendency (e.g., chronic coumadin treatment)
• Patients participating in other clinical study
• Patients with penicillin allergy
• Patients with Augmentin resistant bacteria in cultures