Phase I Trial of Vorinostat (NSC-701852, Suberoylanilide Hydroxamic Acid) and Doxorubicin (NSC-123127, Adriamycin)
Phase I Trial of Vorinostat (NSC-701852, Suberoylanilide Hydroxamic Acid) and Doxorubicin (NSC-123127, Adriamycin)
This phase I trial is studying the side effects and best dose of vorinostat when given together with doxorubicin in treating patients with metastatic or locally advanced solid tumors. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Vorinostat may help doxorubicin work better by making tumor cells more sensitive to the drug.
PRIMARY OBJECTIVES:
I. Determine the safety and tolerability of vorinostat (SAHA) and doxorubicin hydrochloride in patients with metastatic or locally advanced solid tumors.
II. Determine the maximum tolerated dose of vorinostat when administered with doxorubicin hydrochloride in patients treated with this regimen.
SECONDARY OBJECTIVES:
I. Determine the response rate (complete response [CR] and partial response [PR]) and clinical benefits rate (CR, PR, and stable disease > 12 weeks) in patients treated with this regimen.
II. Determine the pharmacokinetics and pharmacodynamics of vorinostat and doxorubicin hydrochloride and their interaction.
III. Determine the effects of vorinostat on histone acetylation in peripheral blood mononuclear cells and tumors.
IV. Determine the effects of vorinostat on DNA damage induced by doxorubicin hydrochloride as a function of topoisomerase II expression.
V. Determine the effects of vorinostat on genes and proteins crucial for the maintenance of chromatin structure.
OUTLINE: This is a non-randomized, open-label, dose-escalation study of vorinostat.
Patients receive oral vorinostat twice daily for 5 doses on days 1-3, 8-10, and 15-17 and doxorubicin hydrochloride IV on days 3, 10, and 17. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients with responding or stable disease after 6 courses of treatment may continue to receive vorinostat alone in the absence of disease progression.
Cohorts of 3-6 patients receive escalating doses of vorinostat until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Up to15 patients are treated at the MTD. Mandatory biopsies are required in these patients. Patients undergo blood collection and tumor biopsies periodically during the study for pharmacologic, pharmacokinetic, pharmacodynamic, and biomarker correlative studies.
After completion of study treatment, patients are followed for at least 30 days.
PROJECTED ACCRUAL: A total of 40 patients will be accrued to this study.
Inclusion Criteria:
Histologically or cytologically confirmed solid tumor malignancies for which no curative therapy exists
Measurable or evaluable disease with tumor that is accessible to biopsy as determined by CT scan or ultrasound
Skin, lymph nodes, or chest wall lesions are allowed provided measurements are confirmed by 2 independent health care professionals
No uncontrolled CNS metastases
Willing to undergo pre- and post-vorinostat tumor biopsies
Life expectancy ≥ 3 months
ECOG performance status 0-2
WBC > 3,000/mm^3
Absolute neutrophil count > 1,500/mm^3
Hemoglobin > 9.0 g/dL
Platelet count > 100,000/mm^3 (transfusion independent)
Creatinine ≤ 2.0 mg/mL
Bilirubin ≤ 1.5 times upper limit of normal (ULN)
AST and ALT ≤ 1.5 times ULN
LVEF > 50%
Fertile patients must use effective contraception during and for 6 months after completion of study treatment
Negative pregnancy test
Not pregnant or nursing
No significant active infection (e.g., pneumonia, cellulitis, or wound abscess)
No history of cardiac failure
No history of long QT syndrome (QTc > 470 msec)
No history of ventricular tachycardia or fibrillation
No history of seizures
No history of allergic reactions attributed to compounds of similar chemical or biological composition to vorinostat or other agents used in the study
More than 3 weeks since prior chemotherapy or radiotherapy (2 weeks for weekly regimens)
More than 2 weeks since prior valproic acid or any other histone deacetylase inhibitors
No prior anthracycline exposure
No other concurrent chemotherapy
No concurrent hormonal therapy except for maintenance therapy with luteinizing-hormone releasing-hormone agonists
No concurrent antiarrhythmics
No concurrent steroids to control brain metastasis
No concurrent colony-stimulating factors (e.g., filgrastim [G-CSF] or sargramostim [GM-CSF]) during the first course of study treatment
No other concurrent investigational agents for primary disease