The purpose of this study is to evaluate and conduct an exploratory comparison of the efficacy and safety of indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) and fluorescein angiography (FA) guided PDT for exudative age-related macular degeneration (AMD) accompanied with polypoidal choroidal vasculopathy (PCV).

PDT with verteporfin has been proven beneficial for patients with AMD. The laser spot size is decided based on FA finding (FA guided PDT). ICGA is needed to detect PCV lesions, such as polypoidal lesions or abnormal network vessels. In clinical practice, PDT based on ICGA (ICGA guided PDT) has and is being conducted for the treatment of AMD with PCV. However, there are no reports on the outcomes of prospective research of PDT for PCV in Japanese patients. Furthermore, there are no reports comparing FA guided PDT and ICGA guided PDT.

We propose to conduct this clinical research in order to investigate the efficacy and safety of PDT for PCV in Japanese patients, and to compare results of FA guided PDT and ICGA guided PDT.

Inclusion Criteria:

• Japanese patients aged 50 years old or older
• Exudative AMD with subfoveal PCV
• Eyes with PCV meets the definite criteria of PCV issued from Japanese study group of Polypoidal Choroidal Vasculopathy
• PCV lesion with subfoveal hemorrhage or exudation
• Lesion size (GLD) of less than 12 MPS Disc area measured by FA and IA.
• Decimal BCVA of 0.1-0.5 at baseline period.

Exclusion Criteria:

• Patients who have RPE tear, vitelliform retinal dystrophy, and central Serous Chorioretinopathy.
• Patients who have other ocular disease with irreversible VA
• Study eyes unable to be taken fundus photos of CNV
• Study eyes received surgery operation within 2 months of the participation to this study or ND:YAG operation within one month
• Pathological myopia
• PCV with cleary identified subsensory retinal CNV (on the RPE) at the baseline examination
• Study eyes which have received any treatments for CNV, such as PDT, transpupillary thermotherapy, laser photocoagulation, and so on.
• Patients who have any physical problem for using angiography or PDT (such as systemic debility, significant diabetes mellitus, significant heart disease, and so on)
• Medical history of porphyria, porphyrin sensitivity, or hypersensitivity to sunlight or bright light.
• Patients with medical history of hypersensitivity to ingredients of Visudyne
• Patients with medical history of hypersensitivity to ingredients of fluorescein or indocyanine green injection
• Patients with hypersensitivity to iodine
• Patients judged inappropriate for this study by the investigator