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Due to poor enrollment
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The aim of this study is to examine the effects of ISIS 113715 monotherapy on insulin sensitivity, glucose and lipid metabolism and energy expenditure in subjects with type 2 diabetes mellitus.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ISIS 113715 | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the effects of ISIS 113715 on hepatic and peripheral insulin sensitivity | ||
| Examine the effect on whole body energy expenditure | ||
| Evaluate the effects on fasting and postprandial glucose excursions | ||
| Evaluate the effects on hemoglobin A1c (HbA1c) |
| Measure | Description | Time Frame |
|---|---|---|
| Expand the safety and tolerability profile for ISIS 113715 | ||
| Assess the effects of ISIS 113715 on rates of basal and insulin stimulated whole body glycerol turnover | ||
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Isis Pharmaceuticals | Ionis Pharmaceuticals, Inc. | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yale - New Haven Hospital | New Haven | Connecticut | 06511 | United States |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C496122 | ISIS-113715 |
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| Assess the effects of ISIS 113715 on insulin suppression of local rates of lipolysis (microdialysis) |
| D004700 | Endocrine System Diseases |