To evaluate the antibody response to each influenza vaccine antigen when administering a single dose to subjects aged 18 years and over

Inclusion Criteria:

• 18 years of age or older

Exclusion Criteria:

• any serious disease such as cancer, autoimmune disease, advanced arteriosclerotic disease or complicated diabetes mellitus, chronic obstructive pulmonary disease (COPD) that requires oxygen therapy, acute or progressive hepatic disease, acute or progressive renal disease, congestive heart failure and bleeding diathesis or conditions associated with prolonged bleeding time
• hypersensitivity to eggs, chicken protein, chicken feathers, influenza viral protein, neomycin or polymyxin or any other component of the vaccine known or suspected (or high risk of developing) impairment/alteration of
• immune function within the past 7 days any acute disease or infections requiring systemic antibiotic or antiviral therapy (chronic antibiotic therapy for urinary tract prophylaxis was acceptable)
• fever within the past 3 days
• history of neurological symptoms or signs, or anaphylactic shock following administration of any vaccine
• within the past 12 months have received more than one injection of influenza vaccine
• Women who are pregnant or women able to bear children but not willing to practice acceptable contraception for the duration of the trial (21 days)