This study is being conducted to see if adding GW679769 (casopitant) to ZOFRAN will significantly decrease the number of patients who experience nausea and vomiting after surgery.

Inclusion criteria:

• History of PONV and/or motion sickness.
• Have not smoked for the last 6 months.
• Having certain types of abdominal, breast or shoulder surgeries.

Exclusion criteria:

• Pregnant or breastfeeding.
• Taking certain medications.
• Have certain pre-existing medical conditions.

Patient-level data for this study will be made available through www.clinicalstudydatarequest.com following the timelines and process described on this site.