Effect of Pyridorin in Patients With Diabetic Nephropathy

A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, 24-Week Study to Evaluate the Safety and Tolerability of Pyridorin (Pyridoxamine Dihydrochloride) in Patients With Diabetic Nephropathy Associated With Type 1 or Type 2 Diabetes

The primary objective of the study is to evaluate the safety and tolerability of Pyridorin (pyridoxamine dihydrochloride) 50 mg given orally twice daily in patients with diabetic kidney disease.

Inclusion Criteria:

• Males and Females (non-pregnant and non-lactating) between 18 and 70 years of age with type 1 or type 2 diabetes

• Sitting blood pressure of <=170/100 mm Hg at weeks -2 and -1

• Hemoglobin A1C <=12% at week -2

• Patients with diagnosis of diabetic nephropathy as defined by

  1. Serum Creatinine <=2.0 mg/dL at weeks -2 and -1
  2. Urinary albumin excretion >=300 mg/24 hours at week -2
  3. Diagnosis of diabetic retinopathy

• Creatinine clearance >=40 mL/min at weeks -2 and -1

• Voluntary written consent to participate in this study

Exclusion Criteria:

• History of allergic or adverse response to any B vitamin
• History of major cardiovascular or cerebrovascular events
• History of cancer except adequately treated basal or squamous cell carcinoma of the skin
• History of diabetic ketoacidosis