To measure meropenem pancreatic tissue penetration in subjects with severe pancreatitis requiring surgery between 30 to 60 minutes after a bolus of 1 g IV meropenem given during the induction period of anesthesia.

Inclusion Criteria:

• Subjects with diagnosis of severe pancreatitis requiring surgery according to the protocol of each Institution.
• Informed consent signed by the subject
• Subjects who have received prophylactic antibiotics for previous invasive procedures different from surgery may be included

Exclusion Criteria:

• Will of the subject not to be included
• Subjects who have not signed the informed consent
• Subjects with known hypersensibility to carbapenems, penicillins, or cephalosporins